Chemical Coordination and Integration NEET PYQReal NEET & AIPMT 2005–2021 questions, year-tagged, with solutions
By the RankUp team, founded by Dr. Deepak Sahu (MBBS Gold Medalist, NEET PG AIR 1731) · Updated
Every Chemical Coordination and Integration question from the NEET & AIPMT papers on this site (2005–2021), newest first. Each is tagged with its paper. Tap an option to check your answer and read the explanation.
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Chemical Coordination and Integration previous year questions
46 questions. Tap an option to check your answer.
Q1NEET 2021
Erythropoietin hormone which stimulates R.B.C. formation is produced by :
Not quite — the answer is D.
The juxtaglomerular cells of the kidney produce erythropoietin, which stimulates RBC formation in the bone marrow. The bone marrow is where RBCs are made, not where the hormone is produced.
Q2NEET 2020 · Q80
Match the following columns and select the correct option. Column - I | Column - II (a) Pituitary gland | (i) Grave's disease (b) Thyroid gland | (ii) Diabetes mellitus (c) Adrenal gland | (iii) Diabetes insipidus (d) Pancreas | (iv) Addison's disease
Not quite — the answer is C.
Low ADH from the pituitary causes diabetes insipidus, hyperthyroidism causes Graves' disease, low adrenal cortex hormones cause Addison's disease, and insulin deficiency from the pancreas causes diabetes mellitus. Hence diabetes insipidus, Graves' disease, Addison's disease, diabetes mellitus is correct.
Q3NEET 2020 · Q81
Select the correct statement.
Not quite — the answer is A.
Glucocorticoids such as cortisol stimulate gluconeogenesis, lipolysis and proteolysis, raising blood glucose. Glucagon causes hyperglycaemia, insulin causes hypoglycaemia, and insulin acts mainly on liver cells and adipocytes, not on pancreatic cells.
Q4NEET 2019 · Q109
How does steroid hormone influence the cellular activities ?
Not quite — the answer is B.
Steroid hormones are lipid soluble; they enter the cell, bind intracellular receptors and the hormone-receptor complex binds the genome to regulate gene expression. cAMP second messengers are used by protein/peptide hormones acting on membrane receptors.
Q5NEET 2019 · Q161
Which of the following glucose transporters is insulin-dependent ?
Not quite — the answer is D.
GLUT4, found in skeletal muscle and adipose tissue, is moved to the cell membrane in response to insulin, making glucose uptake there insulin-dependent. GLUT1, GLUT2 and GLUT3 transport glucose independently of insulin.
Q6NEET 2019 · Q179
Match the following hormones with the respective disease : (a) Insulin — (i) Addison's disease (b) Thyroxin — (ii) Diabetes insipidus (c) Corticoids — (iii) Acromegaly (d) Growth Hormone — (iv) Goitre (v) Diabetes mellitus Select the correct option.
Not quite — the answer is C.
Insulin deficiency causes diabetes mellitus, thyroxine disorders cause goitre, deficient adrenal corticoids cause Addison's disease and excess growth hormone in adults causes acromegaly. Diabetes insipidus is due to ADH deficiency, not insulin.
Q7NEET 2018 · Q140
Which of the following is an amino acid derived hormone?
Not quite — the answer is C.
Epinephrine (adrenaline) is a catecholamine made from the amino acid tyrosine. Estradiol and estriol are steroid hormones made from cholesterol, and ecdysone is an insect steroid hormone.
Q8NEET 2017 · Q86
Hypersecretion of Growth Hormone in adults does not cause further increase in height, because:
Not quite — the answer is B.
Growth in length of long bones happens at the epiphyseal (growth) plates, which ossify and close after adolescence, so excess GH in adults cannot add height. It instead thickens bones of the face, hands and feet (acromegaly), showing the hormone is still active.
Q9NEET 2017 · Q126
A temporary endocrine gland in the human body is:
Not quite — the answer is C.
The corpus luteum forms from the ruptured Graafian follicle after ovulation, secretes progesterone, and degenerates if pregnancy does not follow, so it is temporary. The pineal gland is permanent, and the corpus cardiacum and corpus allatum are insect glands.
Q10NEET 2017 (Gujarati paper) · Q89
Thymosin is responsible for:
Not quite — the answer is C.
The thymus secretes thymosins, which promote the differentiation of T-lymphocytes for cell-mediated immunity and also aid antibody production. Lowering blood calcium is the job of thyrocalcitonin, not thymosin.
Q11NEET 2017 (Gujarati paper) · Q103
Cholecystokinin acts on:
Not quite — the answer is D.
Cholecystokinin (CCK), released by the duodenum, acts on the pancreas to secrete pancreatic enzymes and on the gall bladder to release bile. Gastric glands are stimulated by gastrin, not CCK.
Q12NEET 2016 Phase 2 · Q147
Which hormones do stimulate the production of pancreatic juice and bicarbonate?
Not quite — the answer is C.
Secretin, from the duodenum, makes the exocrine pancreas release water and bicarbonate, and cholecystokinin stimulates secretion of pancreatic enzymes and bile release. Gastrin acts on the stomach, while insulin and glucagon are endocrine pancreatic hormones that regulate blood glucose.
Q13NEET 2016 Phase 2 · Q150
Graves' disease is caused due to
Not quite — the answer is B.
Graves' disease (exophthalmic goitre) is a form of hyperthyroidism caused by excess thyroid hormone, with bulging eyes, high metabolic rate and weight loss. Too little thyroid hormone causes cretinism or myxoedema, and adrenal disorders cause Addison's disease or Cushing's syndrome.
Q14NEET 2016 Phase 2 · Q153
Name a peptide hormone which acts mainly on hepatocytes, adipocytes and enhances cellular glucose uptake and utilization.
Not quite — the answer is A.
Insulin, a peptide hormone from pancreatic beta cells, acts mainly on liver cells and fat cells to increase glucose uptake and use, lowering blood sugar. Glucagon raises blood glucose, and secretin and gastrin are gastrointestinal hormones.
Q15NEET 2016 Phase 2 · Q157
The posterior pituitary gland is not a 'true' endocrine gland because
Not quite — the answer is B.
Oxytocin and vasopressin are made by neurosecretory cells of the hypothalamus and only stored in and released from the posterior pituitary (neurohypophysis), so it makes no hormones of its own. It is ductless and secretes no enzymes, and being regulated by the hypothalamus applies to the anterior pituitary too.
Q16NEET 2016 Phase 1 · Q108
Which of the following pairs of hormones are not antagonistic (having opposite effects) to each other?
Not quite — the answer is D.
Parathormone raises and calcitonin lowers blood calcium; insulin lowers and glucagon raises blood glucose; aldosterone retains Na⁺ and water while ANF promotes their loss. Relaxin (softens pelvic ligaments at parturition) and inhibin (suppresses FSH) act on unrelated targets, so they are not antagonistic.
Q17NEET 2016 Phase 1 · Q147
The amino acid Tryptophan is the precursor for the synthesis of:
Not quite — the answer is A.
Tryptophan is converted to serotonin (5-hydroxytryptamine), which in the pineal gland is converted to melatonin. Thyroid hormones come from tyrosine, while estrogen, progesterone, cortisol and cortisone are steroids derived from cholesterol.
Q18AIPMT 2015
A chemical signal that has both endocrine and neural roles is:
Not quite — the answer is D.
Epinephrine (adrenaline) is released into the blood by the adrenal medulla as a hormone and is also a neurotransmitter of sympathetic nerves. Cortisol, melatonin and calcitonin act only as hormones.
Q19AIPMT 2014
Identify the hormone with its correct matching of source and function:
Not quite — the answer is A.
Melatonin is secreted by the pineal gland and regulates the diurnal (24-hour) sleep-wake rhythm, so this match is correct. Atrial natriuretic factor comes from the atrial wall and lowers blood pressure, growth of female secondary sex organs is due to estrogen, and oxytocin causes milk ejection rather than growth of mammary glands.
Q20AIPMT 2014
Fight-or-flight reactions cause activation of:
Not quite — the answer is B.
In emergencies the sympathetic system stimulates the adrenal medulla to secrete epinephrine and norepinephrine (the fight-or-flight hormones), raising heart rate, blood glucose and alertness. Blood sugar rises rather than falls, and the kidney and parathyroid are not the effectors of this response.
Q21NEET 2013
A pregnant female delivers a baby who suffers from stunted growth, mental retardation, low intelligence quotient and abnormal skin. This is the result of
Not quite — the answer is A.
Iodine deficiency during pregnancy causes hypothyroidism in the developing baby, leading to cretinism with stunted growth, mental retardation, low IQ and abnormal skin. Low growth hormone causes dwarfism without mental retardation.
Q22NEET 2013
Which of the following statements is correct in relation to the endocrine system?
Not quite — the answer is C.
Hormones are defined as non-nutrient chemicals produced in trace amounts that act as intercellular messengers. The adenohypophysis is controlled by hypothalamic hormones via the portal system, not directly by nerves, and releasing hormones come from the hypothalamus, not the pituitary.
Q23NEET 2013
Select the answer which correctly matches the endocrine gland with the hormone it secretes and its function/deficiency symptom:
Not quite — the answer is C.
The thyroid secretes thyroxine, and lack of iodine in the diet causes goitre. Oxytocin is released by the posterior pituitary and GH by the anterior pituitary, and testosterone comes from Leydig cells, not the corpus luteum.
Q24AIPMT 2012 Prelims
Which one of the following pairs of hormones are the examples of those that can easily pass through the cell membrane of the target cell and bind to a receptor inside it (mostly in the nucleus)?
Not quite — the answer is A.
Cortisol and testosterone are lipid-soluble steroid hormones that pass through the cell membrane and bind to intracellular (mostly nuclear) receptors. Insulin, glucagon, somatostatin and oxytocin are peptide hormones that bind to membrane receptors; thyroxine enters the cell but insulin does not.
Q25AIPMT 2012 Prelims
A person entering an empty room suddenly finds a snake right in front on opening the door. Which one of the following is likely to happen in his neuro-hormonal control system ?
Not quite — the answer is B.
In a fright response the sympathetic nervous system stimulates the adrenal medulla to release epinephrine and norepinephrine (fight-or-flight). These hormones come from the medulla, not the adrenal cortex, and the parasympathetic division is not activated in an emergency.
Q26AIPMT 2012 Prelims
What is correct to say about the hormone action in humans ?
Not quite — the answer is D.
FSH is a glycoprotein hormone, so in females it first binds to specific receptors on the membrane of ovarian cells. FSH stimulates follicle growth and oestrogen secretion but not progesterone, glucagon comes from α-cells (not β-cells), and thymosin secretion falls with age.
Q27AIPMT 2011 Mains
The 24 hour (diurnal) rhythm of our body such as the sleep-wake cycle is regulated by the hormone
Not quite — the answer is B.
Melatonin, secreted by the pineal gland, regulates the 24-hour (diurnal) rhythm including the sleep-wake cycle. Adrenaline is the emergency hormone, calcitonin lowers blood calcium and prolactin stimulates milk production.
Q28AIPMT 2011 Prelims
Match the source gland with its respective hormone as well as the function
Not quite — the answer is C.
Vasopressin (ADH) is released from the posterior pituitary and acts on the distal tubule and collecting duct to increase water reabsorption. Calcium is regulated by thyrocalcitonin and parathyroid hormone, oxytocin is released from the posterior pituitary, and the corpus luteum supports pregnancy mainly through progesterone.
Q29AIPMT 2011 Prelims
Given below is an incomplete table about certain hormones, their source glands and one major effect of each on the body in humans. Identify the correct option for the three blanks A, B and C. Gland A – Oestrogen – Maintenance of secondary sexual characters Alpha cells of Islets of Langerhans – B – Raises blood sugar level Anterior pituitary – C – Over secretion leads to gigantism
Not quite — the answer is B.
Oestrogen that maintains female secondary sexual characters comes from the ovary, the α-cells of the islets of Langerhans secrete glucagon which raises blood sugar, and over-secretion of growth hormone from the anterior pituitary causes gigantism. Insulin lowers blood sugar, and calcitonin is from the thyroid.
Q30AIPMT 2010 Mains · Q23
Select the correct matching of a hormone, its source and function. Hormone – Source – Function
Not quite — the answer is B.
Norepinephrine (with epinephrine) from the adrenal medulla is an emergency hormone that raises heart rate, breathing rate and alertness. Vasopressin (ADH) reduces water loss in urine, glucagon comes from alpha cells (beta cells make insulin), and prolactin is secreted by the anterior pituitary.
Q31AIPMT 2010 Prelims · Q155
Which one of the following pairs is incorrectly matched?
Not quite — the answer is B.
Glucagon is secreted by the alpha (α) cells of the islets of Langerhans, while beta (β) cells secrete insulin, so this pair is wrong. Delta cells secrete somatostatin, the corpus luteum secretes relaxin, and insulin deficiency causes diabetes mellitus.
Q32AIPMT 2010 Prelims · Q157
Injury to adrenal cortex is not likely to affect the secretion of which one of the following?
Not quite — the answer is D.
Adrenaline (epinephrine) is made by the adrenal medulla, so damage to the cortex leaves it unaffected. The cortex makes glucocorticoids (cortisol), mineralocorticoids (aldosterone) and adrenal androgens such as DHEA and androstenedione.
Q33AIPMT 2010 Prelims · Q188
Toxic agents present in food which interfere with thyroxine synthesis lead to the development of
Not quite — the answer is D.
Substances in food that block thyroid hormone synthesis (goitrogens) lower thyroxine levels. The pituitary responds by releasing more TSH, so the gland enlarges into a simple (non-toxic) goitre. Thyrotoxicosis and toxic goitre are conditions of excess thyroxine.
Q34AIPMT 2009 Prelims · Q112
A health disorder that results from the deficiency of thyroxine in adults and characterised by (i) a low metabolic rate, (ii) increase in body weight and (iii) tendency to retain water in tissues is:
Not quite — the answer is B.
Myxoedema is the specific adult form of thyroxine deficiency, with low BMR, weight gain and puffy water-retaining tissues. Cretinism is thyroxine deficiency in children, and simple goitre is thyroid enlargement due to iodine shortage.
Q35AIPMT 2008 Prelims · Q154
The blood calcium level is lowered by the deficiency of
Not quite — the answer is B.
Parathormone raises blood Ca²⁺ by mobilising it from bone and increasing reabsorption, so its deficiency causes hypocalcaemia. Calcitonin lowers blood calcium, so a lack of it would tend to raise the level.
Q36AIPMT 2008 Prelims · Q168
In human adult females oxytocin
Not quite — the answer is A.
Oxytocin causes strong contractions of the uterine smooth muscle during birth and triggers milk ejection. It is made in the hypothalamus and released from the posterior pituitary, not the anterior. Mammary gland growth is driven by other hormones such as prolactin, oestrogen and progesterone.
Q37AIPMT 2008 Prelims · Q199
Which of the following pairs of organs includes only the endocrine glands?
Not quite — the answer is B.
Parathyroid and adrenal glands are purely endocrine. The pancreas also has an exocrine part, and the ovary and testis also produce gametes, so each of the other pairs includes an organ with non-endocrine functions.
Q38AIPMT 2007 Prelims · Q151
A person is having problems with calcium and phosphorus metabolism in his body. Which one of following glands may not be functioning properly?
Not quite — the answer is D.
Parathyroid hormone controls blood calcium and phosphate by acting on bone, kidney and intestine, so faulty calcium-phosphorus metabolism points to the parathyroid. Thyroid calcitonin also lowers calcium but is a minor regulator; parotid is a salivary gland.
Q39AIPMT 2007 Prelims · Q186
Compared to a bull a bullock is docile because of
Not quite — the answer is B.
A bullock is a castrated bull; without testes it makes little testosterone, the hormone that drives aggressive male behaviour, so it is docile. Its adrenal and thyroid hormones are not the cause.
Q40AIPMT 2007 Prelims · Q199
Feeling the tremors of an earthquake a scared resident of seventh floor of a multistoried building starts climbing down the stairs rapidly. Which hormone initiated this action?
Not quite — the answer is A.
Fear triggers the sympathetic nervous system to release adrenaline from the adrenal medulla, the 'fight or flight' hormone that raises heart rate, breathing and blood glucose for quick action. Glucagon, gastrin and thyroxine do not mediate emergency responses.
Q41AIPMT 2006 Prelims · Q108
Which one of the following statements is correct ?
Not quite — the answer is B.
The neural and endocrine systems control each other: the hypothalamus (nervous tissue) controls the pituitary, while hormones such as thyroxine and adrenaline change the activity of the nervous system. So the statement that neurons regulate endocrine glands but not the other way round is wrong.
Q42AIPMT 2006 Prelims · Q165
A steroid hormone which regulates glucose metabolism is :
Not quite — the answer is A.
Cortisol is the main glucocorticoid; it raises blood sugar by stimulating gluconeogenesis and other effects on carbohydrate metabolism. 11-deoxycorticosterone acts mainly as a mineralocorticoid on salt balance.
Q43AIPMT 2006 Prelims · Q167
Which one of the following is not a second messenger in hormone action ?
Not quite — the answer is C.
cAMP, cGMP and Ca²⁺ act as second messengers that relay hormone signals inside the cell. Sodium ions are not used as second messengers.
Q44AIPMT 2006 Prelims · Q181
Which of the following is an accumulation and release centre of neurohormones ?
Not quite — the answer is A.
Oxytocin and vasopressin are made by hypothalamic neurons, travel down their axons, and are stored in and released from the posterior pituitary. The hypothalamus produces these neurohormones but the place where they collect and are released is the neurohypophysis.
Q45AIPMT 2006 Prelims · Q185
Which hormone causes dilation of blood vessels, increased oxygen consumption and glycogenolysis ?
Not quite — the answer is C.
Adrenaline (the fight-or-flight hormone) raises oxygen use, breaks down glycogen and widens blood vessels in muscles and heart. Glucagon also causes glycogenolysis but does not produce these vascular and metabolic stress effects.
Q46AIPMT 2005 Prelims · Q188
Secretin and cholecystokinin are digestive hormones. They are secreted in :
Not quite — the answer is C.
When acidic chyme and fat enter the duodenum, its mucosa releases secretin and CCK, which act on the pancreas, liver and gall bladder. The pyloric stomach releases gastrin, not these hormones.
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Questions from this chapter in each paper on this site.
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